The Theme

As mentioned in the Summary, this movie takes the Unknown Unknowns mantra of Rumsfeld HAL [with GW Bush as the Monolith] and has a bit of fun with it by putting J Doe in the path of TERROR [aka Horror].  Or as FF Coppola has Kurtz say in Apocalypse Now "Horror has a face and you must make friends with horror or it will become your enemy".

Here is Otto's Notebook entry on Unknown Unknowns

As the world tried to point out to J Doe with War in Iraq, it is totally dumb to start a war based on something you "don't know that you don't know", but if J Doe WANTS a war then HAL will always GIVE him a war, despite his usual demands [as we see in this movie] that he MUST be given an explanation for everything [especially if it is making you kill yourself].

So first bit of cunning of M Night S is the top text on blackboard, ie about bees and "attributed to Einstein", to confuse it with the other better known [and more applicable] "attributed to Einstein" which is:

"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
- Albert Einstein (1879 - 1955)

Then, under the bees quote is the APPLICABLE quote for the movie, but teacher never gets to it as the PROBLEM starts before the explanation.  That quote is:

"On glossy wires artistically bent,
He draws himself up to his full extent,
His natty wings with self-assurance perk.
His stinging quarters menacingly work.
Poor egotist, he has no way of knowing
But he's as good as anybody going."

We are then shown how J Doe the egotist reacts [badly] once things go wrong, ending up with an Einstein facsimile on TV warning that J Doe has been GIVEN  a warning but TV anchor convinces J Doe it is "business as normal"